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darunavir will raise the stage or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.omaveloxolone will lower the extent or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Omaveloxolone may well decrease systemic exposure of sensitive CYP3A4 substrates. Check prescribing